Treatment in Milan (Italy)

Prof. Salvatore Badalamenti is the Nephrology and Dialysis Unit Director in Humanitas Research Hospital. He has graduated at the Università degli Studi of Milan and is specialised in Medical Nephrology, Liver Diseases and Replacement.

Medical areas of interest:

• clinical nephrology and dialysis, chronic renal failure and its complications (anemia, osteodystrophy)
• preparation of vascular access for hemodialysis
• acid-base balance disorders. continuous renal replacement therapy in intensive care (CRRT)
• hepatorenal syndrome
• emergency medicine

Previous experience:

1990-1995 Polyclinic Hospital, Milan, Italy
He was a Staff grade specialist. Focused on infectious complications in dialysis treatments, particularly hepatitis C and anaemia, and nephrological and dialysis emergencies.

1986-1990 Provincial Hospital Clinic , Barcelona, Spain
He completed his PhD in Renal and Hepatic pathophysiology. Especially focused on the study of renal complications in patients with liver disease.

Research areas of interest: 

• clinical nephrology
• anemia and erythropoietin in renal failure and dialysis
• continuous renal replacement therapy in intensive care (crrt)
• hepatorenal syndrome. 
• phgosis and pentraxine in renal failure

He is a member of the Board of Directors of the Italian Society of Nephrology (SIN)

Teaching experience:

He is Professor of Internal Medicine and Emergency medicine and Professor of Nephrology at Università degli Studi of Milan.

Prof. Michele Ciccarelli is the Pneumology Unit Director in Humanitas Research Hospital.

He has acquired significant experience in managing infectious pneumonias, treating about 300 cases annually. 

He has also acquired a wide experience in managing respiratory allergies of bronchial asthma and COPD with over 500 patients followed in these pathologies.

Previous experience:

1988-1995 Hospital of Niguarda, Milan, Italy
Visiting doctor at the Centre for High Specialisation in Allergology and Clinical Immunology with full-time specialisation in the Department of Pneumology Piazza.

Other medical areas of interest:

• Obstructive pathology of the airways
• Pulmonary infectivity
• Bronchoscopy techniques
• Pulmonary oncology
• Interstitial pneumopathies
• Non-invasive ventilator therapy
• Sleep medicine
• Pneumopathies in the course of systemic diseases

Research areas of interest:

• Lung oncology
• Community and hospital acquired pneumonia
• Bronchial asthma
• Chronic obstructive pulmonary disease

Teaching experience: Medicine and Surgery Professor at “Università degli Studi” of Milan.

Scientific activities: Medicine and Surgery Professor at “Associazione Italiana Pneumologi Ospedalieri” (AIPO).

Prof. Enrico Arnaldi is the Arthroscopic and Reconstructive Surgery of the Knee Unit Director in Humanitas Research Hospital. 
He was the medical apprentice of Dr. Lorenzo Spotorno (a master and pioneer in prosthetic surgery). Since 1984, he has dedicated himself to arthroscopic knee surgery and later on shoulder surgery.

Medical areas of interest: He is specialized in degenerative and post-traumatic shoulder diseases (rotator cuff tendon injuries, glenomeral arthrosis, shoulder instability) and related surgical treatments, arthroscopic (tendon repairs, capsuloplasty, etc.) and open (latarjet stabilization, orthoprosthesis, etc.). 
He also deals with degenerative and post traumatic knee pathologies, with particular attention to the osteoarthritis of the knee (primitive or secondary), the post-traumatic complex capsule-ligamentous instabilities, the lesions of the cruciate ligaments, meniscus and cartilage, and open-air surgical treatments (such as corrective osteotomies, first implant orthoprosthesis and revisions) and arthroscopic (meniscectomies and meniscal sutures, meniscal transplants, ACL reconstruction, treatment of focal cartilage lesions). 

Research areas of interest:
There are many research interests, ranging from biotechnology to meniscal transplants and osteochondral grafts, from allogeneic grafts for reviews from failures of ligamentous reconstruction to patella stabilization.

He practiced his specialty in the US in some of the world-renowned medical institutions along with internationally famous doctors: the University of Pittsburgh (Dr. Freddie Fu, Dr. Harner, Dr. Savio Lee Wo), the Intermountain Hospital in Salt Lake City (Dr. Rosemberg, Dr. Paulos), Dr. E. Wolf (San Francisco), Dr. Helman and Dr. Morrison (Los Angeles), Dr. Nottage, Dr. Esch (San Diego), Dr. Steadman and Dr. Hawkins (Vail), Dr. P. Fowler (London Ontario Canada), and J. P. Warner in Boston University.

He has performed more than 10,000 arthroscopic knee surgeries and approximately 1,200 prosthetic reconstruction of the knee. He has always been very involved in the research works in the area of new biotechnologies, meniscal and osteochondral transplantation, allogeneic grafts for revisions by failures of ligament reconstructions, stabilization of the patella.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=arnaldi+enrico

Prof. Guido Grappiolo is Orthopedics Hip and Prosthesis Unit Director in Humanitas Research Hospital. Since 1991, Prof. Guido Grappiolo began working as a researcher dedicated mainly to hip surgery in cooperation with internationally renowned authors such as: Prof. Ganz Prof. T. Gruen, Prof. D. Blaha (U.S.A.), Prof. H. Wagner (Germany), Prof. E. Morscher (Switzerland).

He collaborates with major international schools in the research of new and modern strategies in the field of minimally invasive prosthetics, computer-assisted surgery and conservative surgery. To encourage research in orthopedics is the main scientific goal of the establishment and organization of the "Foundation Livio Sciutto – NPO", an organization of which Prof. Grappiolo is the scientific director. Playing this role, Prof. Grappiolo has been creating and maintaining contacts with other national and international research institutes, which trained thousands of surgeons coming from every country of the world.

The organization has one of the largest hip replacement database of the world: more than 45.000. Dr. Grappiolo is mentored by Dr. Spotorno (a master and pioneer in prosthetic surgery), and their group studied and developed some of the bestselling prosthesis in the world. His research led him to contact the major international schools with which he collaborates in the search for new strategies of improvement in prosthetic minimally invasive and computer-assisted conservative surgery with the development of new prosthetic models and exploration of new materials.

To date, he has attended over 170 meetings, both national and international, almost every time in the role of speaker or chairman. His name appears as author, in more than 60 publications and articles. He has performed more than 2600 prosthetic surgery (hip, knee and ankle).

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=grappiolo

Dr. Lorenzo Di Mento is the Head of the Traumatology Unit in Humanitas Research Hospital. He is also part of the council of AO Trauma Italy with the role of Community Development. 

He specialized in Orthopaedics and Traumatology at the University of Milan (2000-2005), completing several internships abroad:

• 2003 Marseille (France), Centre Phocea, Dr. Bronsard, vertebral surgery
• 2003 Marseille (France), Hopital Nord, Dr. Poitout, traumatology
• 2003-2004 Basse Terre (Guadeloupe), Centro Ospedaliero de la Basse Terre (CHBT), dr Fleurat, acting as intern (equivalent of the French specializing)

He also completed a Fellowship of AO Trauma International at the Centre Hospitalier Universitaire Vadois (CHUV) in Lausanne (Switzerland) in 2016, at the center of pelvic surgery and treatment of septic complications in orthopedics and traumatology, directed by Dr. Borens.

He surgically treats fractures, both acutely ongoing ones (with intervention of reduction and synthesis as soon as possible, in accordance with soft tissues and the patient’s conditions) and as psthumous traumas (pseudoarthrosis, bad or non consolidation). He handles polyfractured and polytrauma patients. Dr. Di Mento also treats infections in a traumatic environment, such as septic psedutoarthrosis and surgically the minor tumoral bone localizations, such as osteolysis, impending fractures and pathological fractures. 

Publications: https://pubmed.ncbi.nlm.nih.gov/?term=Di+Mento+L 

Prof. Giorgio Walter Canonica is the Head of Personalized Medicine Center: Asthma and Allergy in Humanitas Research Hospital.

Medical areas of interest:
Asthma and allergies 

Research areas of interest: 
T cells: study of different subgroups and their functional role in basic and clinical research (allergy, specific autoimmunity of organs, degenerative diseases of the CNS and cancer).

Molecular events and interactions between immunocompetent cells, inflammatory cells, epithelial cells in allergic inflammation and airway remodelling.

Biomarkers that define the therapeutic response in asthma.

New antiallergenic drugs and new strategies in the treatment of allergic disease.

Clinical and immune-pharmacological activities of modifiers of biological responses such as cytokines, monoclonal antibodies, specific immunotherapy for allergens, etc.

Results of reported patients and assessment of quality of life in patients with respiratory and allergic diseases.

Prof. Canonica coordinated and conducted more than 50 tests (phase II-IV) according to current GCP rules (certification number 2426574, 29/06/2017).

He has also served as an arbitrator for most of the most important international journals - Editor-in-Chief of "Current Opinion in Allergy and Clinical Immunology" – Associated Editor "Annals of Allergy & Clinical Immunology".

Previous experience:
Director of the Degree programme of Lung Diseases at the University of Genoa (1998 - Today) President of the Clinic for Diseases of Allergies and Respiratory - Department of Internal Medicine, University of Genoa - IRCCS AOU San Martino IST

(1997) Director of the Specialized School of Allergy and Clinical Immunology DIMI, University of Genoa

• (1998-present) Full professor of allergies and respiratory diseases, Department of Internal Medicine, University of Genoa
   
• (1995-1998) Full professor of Internal Medicine, Department of Internal Medicine, University of Genoa
   
• (1982) Associate Professor Allergy and Clinical Immunology-Dept. of Internal Medicine
  (1977) Assistant Professor of Internal Medicine - University of Genoa
• (1973) Assistant at the Clinic of Pulmonary Diseases - University of Genoa

Publications:

https://www.ncbi.nlm.nih.gov/pubmed/?term=giorgio+walter+canonica

Dott. Federico Della Rocca is the Prosthetic and Minimally Invasive Hip and Knee Orthopaedics. 

Medical areas of interest: 
Pathology of the hip and knee, with particular interest in prosthetic and arthroscopic hip surgery. He performs about 700 surgeries every year. He has numerous participations as speaker at national and international conferences.

Previous experience:
He was an attending physician at Steadman Hawkins Clinic Hospital, Vail Colorado, USA. 

He gave a great contribution to the development of the GTS (Global Tissue Sparing) hip prosthetic stem and biomechanical rotational stability tests with Prof Thomsen, Heidelberg (Germany) 12/2012.

Research areas of interest: 
Arthroscopic techniques on the hip

Teaching experience: 
Theory and practical courses in arthroscopic and prosthetic hip surgery at Medical Education

Prof. Luca Balzarini is the head of the Department of Diagnostic Imaging in Humanitas Research Hospital. He lectured at the post-graduation school in Radiology at the University of Milan and Pavia and he is member of the European Society of Radiology and of the Italian Society of Medical Radiology (SIRM).
He graduated cum laude in Medicine and Surgery at the University of Milan in 1982 and in 1986 he graduated cum laude at the post-graduation school of Radiology at the University of Milan.

His career started at Istituto Nazionale dei Tumori in Milano where he attended as a PHD student of the University of Milan.
After a long experience abroad, where he developed master expertise in Magnetic Resonance Imaging, he then became Assistant in the Department of Diagnostic radiology at Istituto Nazionale dei Tumori (IRCCS) in Milan where he has this role for 12 years now.

Since 1997 he has been working at Humanitas Research Hospital as head of Magnetic Resonance Section, and then head of Diagnostic Radiology Unit (2006). Nin 2012 he became head of Department of Diagnostic Imaging.

In his high technology Department there are 5 MRI machines (from 1 up to 3 T units), 4 CT scans, and an angiography suite, all radiological techniques are regulated by a system of dose control (Dose Watch).

His team, composed of 25 radiologists, has recognized expertise in several fields of Diagnostic and Interventional Imaging and particularly dedicated in Oncological, Muscle-Skeletal, Neuro and Cardiac Imaging.

Prof. Marco Alloisio is the thoracic surgery Unit Director at Humanitas Research Hospital. He graduated in Medicine in 1976 at Università Statale of Milan, specialized in General Surgery, Oncological and Thoracic Surgery. 

Under the guidance of Professor Umberto Veronesi, from 1977 to 1997 he was an assistant in the divisions of general oncological, otolaryngology and thoracic surgery at the National Cancer Institute of Milan (INT). During this period, he also worked with general surgery, breast surgery, oncological otorhinolaryngology and had several periods spent studying abroad (Paris and New York at the Memorial Sloan Kettering Cancer Center).

In 1997 he started his activity at Humanitas Research Hospital and in 1998 he was appointed Chief of Mini-Invasive Thoracic Surgery. From 2006 he was designated Chief of Thoracic Surgery at the same Institution. Main clinical activity has been focused on Thoracic Surgical Oncology, and in particular all kinds of surgical management of primary and secondary lung cancer, lung metastases, mediastinal tumors and thoracic wall tumors. Prof. Marco Alloisio is president of the Italian League for the fight against cancer (LILT) in Milan, and member of many national and international societies (SIC, SICO, ESSO, ISDE, ACOI, SICT, ESTS).

Author of over 200 publications, including articles and presentations to national and internationals scientific meetings. His engagement in clinical research involves early detection and management of primary lung cancer and his treatment also with video-assisted techniques, successful treatment of lung metastases with new techniques for salvage surgery (multiple sub lobar resections and laser resections) but also aggressive surgery for advanced lung cancers after induction chemotherapy and treatment of the thoracic wall and vertebral bodies. 
In the latter field, he is engaged in the surgical treatment of malignant pleural mesothelioma (extra pleural pneumonectomy) with multimodality approaches in a multicentric Italian cooperative group.

Currently engaged in genetic research studies such as "ERCC1 and B-Tubulin exspression in locally advanced NSCLC treated with platinum/vinorelbin neodjuvant chemotherapy" and in external collaborations with universities and hospitals around the world.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=alloisio+marco

Prof.  Marco Francone is the Cardiovascular Imaging Unit Director in Humanitas Research Hospital.

Medical areas of interest:

Imaging in cardiovascular and pulmonary diseases

Previous experience:

- First level Medical Director at the Department of Radiological, Oncological and Anatomy-Pathological Sciences, at Policlinico Umberto I in Rome

- Past-President, Cardiology Section at the Italian Society of Medical Radiology (SIRM)

Research areas of interest: 

Inflammatory heart disease, cardiomyopathy, imaging of acute myocardial infarction, imaging in cardio-toxicity, imaging of post-COVID patients.

Prof.  Marco Francone is the author of more than 150 indexed scientific papers with an impact factor of more than 500 and has lectured around the world for fifteen years, from the United States to Asia, from Africa to Australia.

Teaching experience:

Full Professor of Radio diagnostics at Humanitas University

Publications:

https://pubmed.ncbi.nlm.nih.gov/?term=marco+francone&sort=pubdate&size=200&show_snippets=off

Dr. Marco Grimaldi is the Diagnostic Neuroradiology Unit Director in Humanitas Research Hospital.

Medical areas of interest:

• magnetic resonance
• computed tomography
• angiography of the central nervous system, brain and spine
• study of the brachial plexus
• functional neuroradiology, in particular, study of cerebral perfusion for perfusion CT related to problems in an emergency regime
• spine dimorphism, in particular of the paediatric age and in rare diseases

He has developed full diagnostic, organizational and managerial autonomy of any problem in outpatient, hospital and emergency neuroradiology.

Research areas of interest:

• Functional imaging studies on coma
• Diagnosis and development of prognostic algorithms
• Research and development, even experimental, of new applications related to technological developments (research on new protocols for the use of the Multidetector Computed Tomography (MDCT), for the use of perfusion CT in vascular and emergency environments finally, study of the trachea in patients at risk of anesthesiology).

Previous experience:

1990 – 2012 Neuroradiologist at Hospital of San Gerardo in Monza, Italy

He was the Director on highly specialised activities related to functional neuroradiology. 

He worked in diagnostic autonomy, organization and management of any problem within neuroradiological outpatient, inpatient and emergency context. 

He is particularly interested in the field of functional neuroradiology, in research and experimental development of new applications also tied to technological developments and creation of new protocols for use of MDCT (use of CT perfusion imaging in the field of vascular and urgency. He was involved in the study of the trachea in patients at high anaesthetic risk), in paediatric radiology with particular reference to diagnosis and clinical management of rare diseases (consultant in the Outpatient Unit for metabolic diseases and in the Outpatient Unit for rare and genetic diseases at the Hospital). He is also interested in the study of problems related to the craniocervical junction.

Teaching experience: 

From 2002 to 2012 he has been a professor at Milano-Bicocca University of Milan.

From 2002 to 2012 : Professor of the courses "Technique and diagnostics for images I", "Technique and diagnostics for images II" and "Semeiotics neuroradiological CT" for the degree in Medical Radiology for Images and Radiotherapy.
From 2003 to 2012: Professor of the course "Functional Brain Diagnostics" for the Degree in Physiotherapy. 
From 2003 to 2012: Professor for the Degree Course in Neurotherapy and psychomotricity of the developmental age.
From 2006 to 2009: Lecturer at the School of Specialization in Radiodiagnostics.

Prof. Dr. Maria Grazia Bordoni is the Vascular Surgery Unit Director in Humanitas Research Hospital. She has graduated at Università degli Studi of Milan and specialised as a vascular surgeon and since then she has been interested in vascular surgery in all its aspects.

Medical areas of interest:

Her main specialties are endovascular surgery and treatment of the large vessels of the abdomen and thorax (aorta, thoracic cavity), carotid surgery, endovascular and surgical treatments for arteries of the lower limbs, preparation of complex vascular access in hemodialysis, phlebology, diagnosis and treatment of vascular malformations. 

Research areas of interest: 

When it comes to the research activity, Dr. Bordoni is mainly dealing with early treatment of acute ischemic strokes and stimulation of the carotid baroreceptors in patients with heart failure. Prof. Bordoni has performed more than 2000 surgeries as first surgeon in her Humanitas career. 

Since 2005, she is also Milan University professor: she teaches General Surgery and focuses on the topic of vascular and surgical emergencies.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=bordoni+mg

Dr. Maurizio Fornari is the Head of the Neurosurgery Unit in Humanitas Research Hospital.

After his specialization in neurosurgery in 1979 at the University of Milan, Dr. Fornari has followed courses in neurosurgery at Mount Sinai Hospital, New York (USA) and advanced courses in Spinal Surgery and skull base at the Center St. Louis (USA) and the Center of Albuquerque (USA).

Dr. Fornari specializes in the treatment of all major diseases of the central and peripheral nervous system, from the compression of the spinal nerves (lumbar and cervical disc hernias, stenosis of the cervical canal, instability of the spine, spinal cord tumors), primary and secondary brain tumors, to congenital malformations of the central nervous system. Dr. Fornari is a recognized leader in the development of computer assisted spine surgery.

Dr. Fornari is a recognized leader in the development of minimally invasive surgery, who among the first has adopted bloodless methods such as micro decompression with unilateral approach for the treatment of lumbar stenosis instead of the much more invasive laminectomy.

Another dreaded disease, sometimes associated with stenosis or lumbar spondylolisthesis, which Dr. Fornari is approaching for quite a long time with the help of spinal navigation systems and intraoperative CT scan, which helps the work of the surgeon during the intervention, reducing invasiveness and risks for the patient, represent lumbar instability.

He and his team perform more than 1.300 surgeries a year, and he has one of the most important case studies in the world (data from a few years ago published in the Journal of Neurosurgery: 
http://thejns.org/action/doSearch?displaySummary=false&AllField=maurizio+fornari.) 

Since 2012, he teaches at the University of Milan. He is also Assistant Editor of "Advanced Technology in Neurosurgery" published by Sprinter Verlag Berlin Heldelberg (1988).

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=fornari%m

Prof. Bruno Bernardini is the Neurological Rehabilitation Unit Director in Humanitas Research Hospital. 

Medical areas of interest:

Rehabilitation in acute-subacute phase of disabled patients for neurological diseases (stroke, cranial-encephalic and medullary trauma, tumors of the nervous system, neuropathies). Hospital risk of fragile elderly patients. Orthogeriatrics.

Research areas of interest:
Post-operative rehabilitation indicators and process-outcome measures for patient prognostic stratification and clinical performance evaluation. 

He is the coordinator of a multicentre study for the application of process-outcome indicators in rehabilitation. The study involves hospital and extra-hospital facilities in Lombardy, Liguria and other regions of Central and Northern Italy.

Previous experience:

2005-2007 Galliera Hospital Authority, Genoa, Italy

Director of the Functional Recovery structure.

Member of the work group for defining the Regional Plan of rehabilitation work 2006-2009 in the Liguria region.

Evaluation, treatment and facilitation of care processes in patients in Neurology, Intensive Care, Neuro-surgery, Intermediate Care, Orthopaedic and Home Care. 

Outpatient work as a physiatric specialist, with a specific sector on the rehabilitation of the pelvic floor.

Development of processes in diagnostic and therapeutic hospital care (especially lumbar-sciatica, joint replacements, cardiac failure, femur fractures and most fast-track urological operations).

1988-1995 Hospital of Niguarda, Milan, Italy
Visiting doctor at the Centre for High Specialisation in Allergology and Clinical Immunology with full-time specialisation in the Department of Pneumology Piazza.

Teaching experience: Medicine Professor at the University of Genoa.

Scientific activities: Member of the board of directors and Geriatric area contact person at “Italian Urodynamic Society Continence, Neuro-Urology, Pelvic Floor”

Prof. Arturo Chiti graduated in Medicine and Surgery at the University of Milan in 1989, and in the same year he entered the Post graduated School in Nuclear Medicine at the University of Milan, where he got his degree in 1993. In the same year he started working as Associate Chief at the National Cancer Institute in Milan, where he began his clinic and scientific experience in Oncology.
In 1997, he got the European Board of Nuclear Medicine fellowship.

In June 2000 he started leading the Nuclear Medicine Department at Humanitas Research Hospital.

On March 1, 2015 he was appointed Full Professor in Diagnostic Imaging and Radiotherapy at the Humanitas University in Milan, where he is also elected member of the Board.

Prof. Chiti is the Unit Director of the Nuclear Medicine Unit in Humanitas Research Hospital. He is the Director of the Post Graduate School in Diagnostic Imaging at Humanitas University. He is member of the Technical and Scientific Committee of the National Centre for Oncologic Adrotherapy (CNAO).

Arturo Chiti is co-author of several papers (www.scopus.com, www.pubmed.com) with an H-index of 30 (July 2016), wrote some books’ chapters and contributed to many abstracts presented at international and national meetings.
He is Honorary Editor of the European Journal of Nuclear Medicine and Molecular Imaging and reviewer for several international journals and grant applications.

He is a well-known invited speaker at numerous international congresses and conferences.

Prof. Arturo Chiti is the President of the European Association of Nuclear Medicine (EANM), where he has been active for more than 10 years.

He is also acting as an expert consultant for International Atomic Energy Agency (IAEA) and is member of the International Commission on Radiation Units and Measurements (ICRU).

He was awarded the honorary membership of the European Society for Therapeutic Radiology and Oncology (ESTRO); the Tom Miller Memorial Lecture Award from the Society of Nuclear Medicine and Molecular Imaging and the Hevesy Gyorgy award from the Hungarian Society of Nuclear Medicine.

Publications:

https://www.ncbi.nlm.nih.gov/pubmed/?term=chiti+arturo

Prof. Antonio Costanzo is the Dermatology Unit Director in Humanitas Research Hospital. He graduated with his MD degree in Medicine and Surgery from the University of Rome, La Sapienza in 1994. He then went on to complete post-graduate study and received a speciality degree in Internal Medicine in 1999 and a Dermatology speciality degree in 2006.

Medical areas of interest:

• Inflammatory and autoimmune skin diseases (Psoriasis, Atopic Dermatitis, Alopecia Areata, Chronic Urticaria, Suppurative Hydroadenitis, Scleroderma, Lupus)
• Personalized Medicine, Biological Psoriasis Therapy
• Dermatological Oncology (Melanoma, Actinic Keratosis, Basocellular and Spinocellular Epitheliomas).
• Prevention of skin neoplasms (dermatoscopy, computer mapping of moles).
• Dermatological surgery

Previous experience:

• Director of Dermatology Unit at Sant’Andrea Hospital in Vercelli
• University Researcher/Hospital Assistant at Tor Vergata Hospital 

Research areas of interest: 

• Psoriasis pathogenesis of other inflammatory and autoimmune skin diseases
• Pathogenesis of skin neoplasms
• Genetic disorders of the skin

His clinical research is focused on the characterization of the activity of biologics in psoriasis and psoriatic arthritis. This research is strictly linked to basic research activity on the pathogenesis of psoriasis and on the use of pharmacogenetic approach to predict the efficacy and safety of biologics in psoriasis.

In the past, Professor Costanzo has collaborated to the characterization of basic mechanisms of TNF inflammatory signalling in epithelial cells and NFkappaB regulation by different stimuli. More recently his research group has collaborated to the discovery of IL-21 as critical mediator of keratinocyte proliferation in psoriasis. Professor Costanzo has authored or co-authored more than 120 publications in internationally peer-reviewed journals.

Teaching experience: Full Professor of Dermatology at Humanitas University

Publications: https://www.ncbi.nlm.nih.gov/pubmed/?term=Costanzo+A 

Prof. Alessandro Repici is the Director of the Gastroenterology and Digestive endoscopy Unit in Humanitas Research Hospital. Graduated in Medicine and Surgery in 1990 and the following year he won a scholarship at the Department of Gastroenterology Molinette hospital in Turin, where he began his practice in digestive endoscopy. In 1992, he worked with Prof. Claude Liguory as a fellow at the American Hospital in Paris.

In 1994 he became a specialist in Gastroenterology and Digestive Endoscopy at the University of Messina and worked in the Department of Gastroenterology, Ospedale Maggiore Molinette of Turin.

In the following years, he has been working at the Service of Digestive Endoscopy of Altona Hospital in Hamburg, directed by prof. Hagenmuller, and in the Department of Gastroenterology Molinette Hospital in Turin, directed by prof. Rizzetto. In 1999, he was a Research Fellow at the Center for Oncological and Operative Endoscopy of Wellsley Hospital in Toronto.

He teaches Gastroenterology and Digestive Endoscopy at the School of Specialization in Oncology since 2000, at the University of Turin since 2004 and Endoscopy Diagnostic Techniques and Operations at the School of Specialization in General Surgery I and II of the University of Turin.

The clinical activity and research of Prof. Repici mainly focuses on the development of new endoscopic techniques in the field of diagnosis and therapy, with particular attention to new methods of endoscopic removal of cancerous lesions and early in the palliation of advanced gastrointestinal malignancies.

Prof. Repici is coordinator, principal investigator and co-investigator in more than 50 studies, including phase II and III for FDA and EMA approval of new molecules and new instruments for diagnostic and operational endoscopy. 

Prof. Repici collaborates on research projects in the field of endoscopy with the University of Rotterdam, in Haifa, in New York and with several Italian centers. He is a member of various national and international scientific society of Gastroenterology and Digestive Endoscopy.

Publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=repici+alessandro

Prof. Andrea Lania has graduated at the Università degli Studi of Milan and is specialized in endocrinology. He is the Unit Director of Endocrinology and Diabetology in Humanitas Research Hospital and his specialization is pituitary diseases, pituitary adenomas, thyroid cancer, pancreatic neuroendocrine tumors, poorly differentiated neuroendocrine carcinomas.

Medical areas of interest:
Pituitary tumors, hypopituitarism, acromegaly, Cushing’s disease and syndrome, neuroendocrine tumors, thyroid and thyroid diseases, adrenal and adrenal diseases, hypogonadism.

Research areas of interest:
Study of the pathogenetic mechanisms of pituitary and neuroendocrine tumors, of the molecular mechanisms responsible for the different response of pituitary and neuroendocrine tumors to medical therapy.

Prof. Lania published 198 peer-reviewed papers (Google Scholar H-Index 47; Scopus H-Index 38, cit tot 4604)

Prof. Lania has a long standing expertise in the field of intra-cellular signaling in endocrine tumors. In particular, in the past ten years, he contributed to analyze the role of PKA regulatory subunits in the pathogenesis and control of cell proliferation of endocrine tumors. Moreover, he contributed to define the role of SSTR5 domains involved in the intracellular trafficking of this receptor in human pituitary cells and to analyze the impact of DR2R and SSTR2&5 polymorphic variants on both the clinical outcome and response to medical treatment in patients with pituitary tumors.

Recently, he contributed to identify the role of cytoskeleton protein FLNA in mediating both intracellular signaling and membrane targeting of somatostatin type 2 receptor and D2R in pituitary and pancreatic neuroendocrine tumors. Finally, he contributed to explore the intracellular mechanisms possibly involved in mediating the interplay between drugs commonly used in the treatment of neuroendocrine tumors.

Previous experience:
2005-2008 Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
Director of Endocrinologic Day Hospital and surgery on pituitary disorders. 

Publications: https://www.ncbi.nlm.nih.gov/pubmed?term=lania%20A 

Dr. Corrado Lodigiani has been assistant at the Thrombosis Centre of Humanitas research Hospital from 1998 to 2013 and he became Unit Director in 2013. 

Humanitas Thrombosis Center is a state-of-the-art service for the proper management of the diagnosis and therapy of venous thromboembolic pathology (deep and superficial venous thrombosis, pulmonary thromboembolism, visceral venous thrombosis) and arterial (myocardial infarction, cerebral stroke, peripheral arterial disease). 
Other also rare diseases treated are atypical thrombosis, such as the vascular circulation of the retina, the hearing system and the placental circulation during pregnancy. 

Dr. Lodigiani adopts the multidisciplinary approach and works in collaboration with all medical and surgical specialties. In particular, he carries out clinical and instrumental diagnostics (vascular ecocolordoppler) and research on the causes, diagnosis and therapy of thrombotic and bleeding disorders, congenital and acquired. His clinical activity also involves the diagnosis and management of patients suffering from bleeding diseases, such as haemophilia, von Willebrand’s disease and platelet diseases.

Medical areas of interest:  

In recent years, he has devoted himself with particular interest to the testing, in the role of Principal Investigator in International Clinical Studies, of new antithrombotic drugs and, above all, anticoagulants, which are about to be marketed and will constitute a valid and safe alternative to traditional oral anticoagulant therapy (DOACs). He is also working, with great interest, on researching the causes of idiopathic infertility and the usefulness and effectiveness of some therapeutic strategies, such as the use of anticoagulant drugs, improving the results of artificial insemination procedures. He is the author of numerous articles in international scientific journals and speaker at numerous national and international conferences.

Dr. Daniela Pini is the Head of the Cardio-respiratory rehabilitation Unit.

Medical areas of interest: Dr. Daniela Pini has been working and researching heart failure and has gained considerable experience in the management of advanced forms of this pathology. She is also very interested in the evaluation and "overall" management of patients suffering from this disease, which mainly affects elderly people and who already have other chronic diseases, which, if neglected, can easily impair the effectiveness of treatment for heart failure itself.

Research areas of interest: new therapies for advanced heart failure: replacement therapy of the heart with mechanical assistance devices to the circulation or heart transplant. New drugs and devices. Multidisciplinary patient management programs.

Further information of interest: thanks to the high competence of cardiosurgeons, electrophysiologists and hemodynamists, Humanitas can count, as a clinical cardiologist, on a team that allows it to offer the patient all the range of therapeutic options for heart failure.

From June 2000 to October 2001 she was Visiting Assistant Professor at the Cardiovascular Division Hospital of the University of Pennsylvania. During this period, she worked in the Heart Failure/Heart Transplantation Program, where she participated in the management of patients with advanced heart failure waiting for transplantation, dealing in particular with medical complications in patients with mechanical assistance devices. She has also worked with kidney, kidney-pancreas, pancreas-insulae, lung, liver and heart transplant teams, dealing with the multiple aspects of managing solid organ transplant recipients.

She worked in the Niguarda Ca' Granda Hospital, at the Cardiomyopathy and Heart Transplantation Service, dealing mainly with patients with advanced heart failure and undergoing a cardiac transplant.

Dr. Pini is a member of the coordination committee of the Decompensation Area of the National Association of Medical Hospital Cardiologists – ANMCO. In the last two years she has been mainly concerned on building a network of “heart failure clinics” on the national territory.